Bibliography & Scientific Contributions
Publications &
Contributions
Author/co-author of over 30 scientific publications and multiple international conference presentations, and delivered trainings in advanced university courses.
Selected publications
Not so cold! Improving the thermostability of mRNA vaccines
Optimal self-assembly of lipid nanoparticles (LNP) in a ring micromixer
Mixing of Monoclonal Antibody Formulated Drug Substance Solutions in Square Disposable Vessels
Impact of tubing material on stability and filling accuracy of biologic drug product
Mechanistic understanding of metal-catalyzed oxidation of polysorbate 80 and monoclonal antibody in biotherapeutic formulations
Folate-Targeted Gene Transfer in Vivo.
Critical assessment of the nuclear import of plasmid during cationic lipid-mediated gene transfer
Electric pulses increase the immunogenicity of an influenza DNA vaccine injected intramuscularly in the mouse.
Synthesis, Activity and SAR Studies of Novel Cationic Lipids for DNA Transfer
Efficient purification of plasmid DNA for gene transfer using Triple-Helix Affinity Chromatography
Other publications
Not so cold! Improving the thermostability of mRNA vaccines.
Haensler J., Even L., Wils P., Bensaid F., Dias A., Deng H., Karve S., De Rosa F. · Expert review of Vaccines 24 (2025) 1149–1162
Impact of tubing material on stability and filling accuracy of biologic drug product.
Poumarede L, Audat H., Pellet C., de la Motte Saint Pierre M., Narradon C., Bensaid F., Nakach M., Authelin J.R., Wils P · Int. J. Pharm 654 (2024) 123927
Optimal self-assembly of lipid nanoparticles (LNP) in a ring micromixer.
Ripoll M., Martin E., Enot M., Robbe O., Rapisarda C., Nicolai M.C., Deliot A., Tabeling P., Authelin J.R., Nakach M., Wils P · Nature Scientific Reports 12 (2022) 9483
Mixing of Monoclonal Antibody Formulated Drug Substance Solutions in Square Disposable Vessels.
Nakach M., Amine C., Pellet C., Bensaid F., Authelin J.R., Wils P · J. Pharm. Sci. (2022) 1-15
Mechanistic understanding of metal-catalyzed oxidation of polysorbate 80 and monoclonal antibody in biotherapeutic formulations.
Bensaid F., Dagallier C., Authelin J.R., Audat H., Filipe V., Narradon C., WILS P. · Int. J. Pharm.5 (2022) 121496
NLS bioconjugates for targeting therapeutic genes to the nucleus.
Escriou V., CARRIERE M., Scherman D., Wils P., · Adv. Drug Del. Rev., 55 (2003) 295-306.
Folate-targeted, cationic-liposome mediated gene transfer into disseminated peritoneal tumors.
REDDY J.A., ABBURI C., HOFLAND H.E.J., HOWARD S.J., VLAHOV I., WILS P., LEAMON C.P. · Gene Ther., 9 (2002) 1542-1550.
Folate targeted gene transfer in vivo.
HOFLAND H.E.J., MASSON C., IGINLA S., OSETINSKY I., REDDY J.A., LEAMON C.P., SCHERMAN D.; BESSODES M., WILS P. · Mol. Therapy, 5 (2002) 739-744.
Critical assessment of the nuclear import of plasmid during cationic lipid-mediated gene transfer.
Escriou V., CARRIERE M., Bussone F., Wils P., Scherman D. · J. Gene Med., 3 (2001) 179-187.
Optimization of plasmids for gene delivery
Escriou V., CARRIERE M., NEVES C., WILS P., SOUBRIER F., MAHFOUDI M., Scherman D. · STP Pharma Science 11 (2001) 5-10.
Electric pulses increase the immunogenicity of an influenza DNA vaccine injected intramuscularly in the mouse.
BACHY M., BOUDET F., BUREAU M., GIRERD-CHAMBAZ Y., WILS P., SCHERMAN D., MERIC C. · Vaccine, 19 (2001) 1688-1693.
Novel method for covalent fluorescent labeling of plasmid DNA that maintains structural integrity of the plasmid.
Neves C., Byk G., Escriou V., Bussone F., Scherman D., Wils P. · Bioconjug Chem., 11 (2000) 51-55.
Intracellular fate and nuclear targeting of plasmid DNA.
NEVES C., ESCRIOU V., BYK G., SCHERMAN D., WILS P. · Cell Biol. Toxicol., 15 (1999) 193-202.
Coupling of a targeting peptide to plasmid DNA by covalent triple helix formation.
NEVES C., BYK G., SCHERMAN D., WILS P. · FEBS Lett., 453 (1999) 41-45.
Cellular uptake of cationic lipid/DNA complexes by cultured myoblasts and myotubes
HELBLING-LECLERC A., SCHERMAN D., WILS P. · Biochim. Biophys. Acta, 1418 (1999) 165-175.
Synthetic DNA-compacting peptides derived from human sequence enhance cationic lipid-mediated gene transfer in vitro and in vivo.
SCHWARTZ B., IVANOV M.A., PITARD B., ESCRIOU V., RANGARA R., BYK G., WILS P., CROUZET J., SCHERMAN D. · Gene Ther., 6 (1999) 282-292.
Coupling of nuclear localization signals to plasmid DNA and specific interaction of the conjugates with importin .
CIOLINA C., BYK G., BLANCHE F., THUILLIER V., SCHERMAN D., WILS P. · Bioconjugate Chem., 10 (1999) 49-55
Application of lipids and plasmid design for gene delivery to mammalian cells.
SCHERMAN D., BESSODES M., CAMERON B., HERSCOVICI J., HOFLAND H., PITARD B., SOUBRIER F., WILS P., CROUZET J. · Curr. Opin. Biotech., 9 (1998) 480-485.
Cationic lipid-mediated gene transfer: analysis of cellular uptake and nuclear import of plasmid DNA.
ESCRIOU V., CIOLINA C., HELBLING-LECLERC A., WILS P., SCHERMAN D. · Cell Biol. Toxicol., 14 (1998) 95-104
Cationic lipid-mediated gene transfer: effect of serum on cellular uptake and intracellular fate of lipopolyamine/DNA complexes.
ESCRIOU V., CIOLINA C., LACROIX F., BYK G., SCHERMAN D., WILS P. · Biochim. Biophys. Acta, 1368 (1998) 276-288.
Synthesis, Activity and SAR Studies of Novel Cationic Lipids for DNA Transfer.
Byk G., Dubertret C., Escriou V., Frederic M., Jaslin G., Rangara R., Pitard B., Crouzet J., Wils P., Schwartz B. and Scherman D. · J. Med. Chem., 41 (1998) 224 -235
A new DNA vehicle for non viral gene therapy: supercoiled minicircle.
DARQUET A.M., CAMERON B., WILS P., SCHERMAN D., CROUZET J. · Gene Ther., 4 (1997) 1341-1349.
Triple-helix formation on plasmid DNA determined by a size exclusion chromatographic method.
ESCRIOU V., LAGNEAUX D., CROUZET J., WILS P., SCHERMAN D. · Anal. Biochem., 248 (1997) 102-110.
Efficient purification of plasmid DNA for gene transfer using Triple-Helix Affinity Chromatography.
WILS P., ESCRIOU V., WARNERY A., LACROIX F., LAGNEAUX D., OLLIVIER M., CROUZET J., MAYAUX J.F., SCHERMAN D. · Gene Ther., 4 (1997) 323-330.
Detection of the multidrug resistance P-glycoprotein in healthy tissues : the example of the blood-brain barrier
LECHARDEUR D., PHUNG-BA V., WILS P., SCHERMAN D. · Ann. Biol. Clin., 54 (1995) 31-36.
Interaction of Pristinamycin Ia with P-glycoprotein in human intestinal epithelial cells.
PHUNG-BA V., WARNERY A., SCHERMAN D., WILS P. · Eur. J. Pharm., 288 (1995) 187-192.
Differentiated intestinal epithelial cell lines as in vitro models for predicting the intestinal absorption of drugs.
WILS P., WARNERY A., PHUNG-BA V., SCHERMAN D. · Cell Biol. Toxicol., 10 (1994) 393-397.
Polarized transport of docetaxel and vinblastine mediated by P-glycoprotein in human intestinal epithelial cells.
WILS P., PHUNG-BA V., WARNERY A., RAEISSI S., HIDALGO I., SCHERMAN D. · Biochem. Pharmacol., 48 (1994) 1528-1530.
High lipophilicity decreases drug transport across intestinal epithelial cells.
WILS P., WARNERY A., PHUNG-BA V., LEGRAIN S., SCHERMAN D. · J. Pharmacol. Exp. Ther., 269 (1994) 654-658.
HT29-18-C1 intestinal cells : a new model for studying the epithelial transport of drugs.
WILS P., LEGRAIN S., FRENOIS E., SCHERMAN D. · Biochim. Biophys. Acta, 1177 (1993) 134-138.
Decreased accessibility of globotriaosylceramide associated with decreased tumorigenicity in Burkitt's lymphoma variants induced by immunoselection.
JUNQUA S., LARSEN A., WILS P., MISHAL Z., WIELS J., LE PECQ J.B. · Cancer Res., 49 (1989) 6480-6486.
Comparison of inhibitory effect of galactose analogs on the binding and cytotoxicity of an anti-globotriaosylceramide monoclonal antibody coupled or not to pokeweed antiviral protein.
JUNQUA S., WILS P., MISHAL Z., LE PECQ J.B. · Eur. J. Immunol., 17 (1987) 459-464.
Determination of antibody-complement mediated cytotoxicity using ATP release induced by a monoclonal antibody against the Burkitt lymphoma associated globotriaosylceramide antigen.
WILS P., JUNQUA S., LE PECQ J.B. · J. Immunol. Methods, 87 (1986) 217-222.
Recent podium presentations
Challenges and Opportunities in the Formulation and Process Development of mRNA Vaccines
Drug Delivery and Formulation Summit — Singapore, November 18-19, 2024
Unlocking mRNA Vaccines : From Platform to Products
mRNA Conference — Frankfurt, 28-30 January 2025
Developing mRNA Vaccines : From Platform to Products
SF Nano 11th Annual Meeting — Lyon, 24-26 November 2025
Formulating Antibodies and mRNA : Common Strategies and Different Challenges
Drug Delivery and Formulation Summit — Berlin, May 19, 2026